Assessment of Creatinine and Urea in Individuals with Various ABO Blood Types at Madonna University

Johnkennedy Nnodim *

Department of Medical Laboratory Science, Faculty of Health Science, Imo State University, Owerri, Nigeria.

Alabi Olubunmi

Department of Medical Laboratory Science, Faculty of Health Sciences, Madonna University, Nigeria, Elele Campus, Rivers State, Nigeria.

*Author to whom correspondence should be addressed.


ABO blood types have historically been mainly linked to organ transplantation and blood transfusion compatibility. Beyond their traditional use in transfusion medicine, ABO blood types may also be associated with other elements of health and illness, according to new study. This study's objective is to assess the creatinine and urea concentrations in subjects at Madonna University who belong to various ABO blood groups. The study included one hundred and seventy-eight (178) Madonna University students. Urease Berthelot's method was used to measure urea, while Modified Jaffe's slot reaction method was used to determine creatinine. The ABO blood grouping system was used to determine ABO blood groups. The results were presented as mean ± SD. Data obtained from the study were analyzed using independent sample t-test and one-way analysis of variance which was used to compare mean, values and considered significant at p<0.05 and non-significant at p>0.05. The study's findings indicate that among the blood types, those with blood type AB have the highest mean levels of creatinine (1.095±0.1513 mg/dl) and urea (32.96±7.815 mg/d). In addition, the mean urea level in males is 29.07±5.506 mg/dl and in females it is 28.85±6.411 mg/dl. Males have a mean creatinine level of 0.908±0.1662 mg/dl while females have a mean level of 0.847±0.2032 mg/dl. Notably, the creatinine p-value (p=0.029*) demonstrates statistical significance and points to a variable in creatinine levels associated to gender. Notably, among the blood types, those aged 36 to 45 have the greatest mean levels of creatinine (0.902±0.0273 mg/dl) and urea (28.46±0.763 mg/dl). Notably, age did not significantly differ at any level (p>0.05). In conclusion, blood type AB persons consistently differ significantly from blood types A, B, and O. They also consistently show the highest levels of urea and creatinine among all blood types. This indicates that Blood group AB probably have higher urea and creatinine levels, it is advised that they be constantly watched for any kidney-related problems.

Keywords: Urea, creatinine, subjects, different ABO blood group

How to Cite

Nnodim , J., & Olubunmi , A. (2024). Assessment of Creatinine and Urea in Individuals with Various ABO Blood Types at Madonna University. International Journal of Advances in Nephrology Research, 7(1), 7–12. Retrieved from


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