An Evaluation of Anti-Diabetic Activity of Ethanolic Extract of Asparagus racemosus in Alloxan Induced Rat Model
Published: 2023-08-02
Page: 60-68
Issue: 2023 - Volume 6 [Issue 1]
Isratul Jannat Mim
Department of Pharmacy, University of Asia Pacific, Farmgate, Dhaka, Bangladesh.
Farhana Yesmin Peya
Department of Pharmacy, University of Asia Pacific, Farmgate, Dhaka, Bangladesh.
Md. Mustafiz Chowdhury
Department of Pharmacy, University of Chittagong, Bangladesh.
Tasnimur Rahman Khan
Department of Pharmacy, University of Asia Pacific, Farmgate, Dhaka, Bangladesh.
Souvik Kumar Mandal
Department of Pharmacy, Gono Bishwabidyalay, Mirzanagor, Savar, Dhaka, Bangladesh.
Fahmida Maliha
Department of Pharmacy, East West University, Dhaka 1212, Bangladesh.
Masruk Alam
Department of Pharmacy, Southeast University, Dhaka, Bangladesh.
Tasnia Rahman
Department of Pharmacy, University of Asia Pacific, Farmgate, Dhaka, Bangladesh.
Rafat Tashin *
Department of Pharmacy, University of Asia Pacific, Farmgate, Dhaka, Bangladesh.
*Author to whom correspondence should be addressed.
Abstract
From traditional and widely used medications in every culture to standardized and tritated herbal extracts, all fall under the umbrella term "herbal medicine," which is defined as the use of medicinal plants for the prevention and treatment of illness. In this research, rats were given Asparagus racemosus leaf extract to test for anti-diabetic activity, liver, kidney, and lipid profiles. After receiving alloxan and extract at low, medium, and high doses, there was a dose-dependent drop in body weight. This weight reduction is minimal when compared to the positive metformin, alloxan control, and alloxan + metformin groups. Groups 8, 9, and 10 will see an increase in body weight. Only metformin with a large dose of extract resulted in a statistically significant (p<0.05) decrease in blood glucose levels. Groups 3 and 4 had decreased blood sugar levels, but the findings were not statistically significant. The SGPT level did not reduce statistically substantially across all treatment groups. Only the high dose, however, resulted in a statistically (p<0.05) decrease in SGOT levels. Throughout the renal function test, creatinine levels decreased in all groups, which was statistically significant (p<0.05). At medium and high dosages, the quantity of urea in the blood statistically significant (p<0.05) decrease. Only the medium and high dosages lowered cholesterol levels across all groups. Triglyceride levels decreased in all groups, although they were not statistically significant. Only the highest dose resulted in a statistically significant (p<0.05) decrease in LDL levels. HDL values increased significantly significant (p<0.05) at medium and high dosages. The findings indicate that A. racemosus has potential for the creation of standardized phytomedicine for the treatment of patients with diabetes, cardiovascular disease, liver disease, and renal illness.
Keywords: Herbal medicine, antidiabetic, cholestererol, creatinine, LDL, HDL
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