International Journal of Advances in Nephrology Research

Abstract

Haematological parameters have been implicated in health indices. Aspartame is associated with elevated blood glucose level and toxicity in some body organs by alteration of their tissue histology. This study investigated the ameliorative potential of Moringa oleifera seed extract on adult male Albno Wistar rats following aspartame consumption. The rats were separated into nine groups and left to acclimatize for two weeks. The experiment lasted for 28 days during which various administration and measurements were carried out. On the 29^th day the rats were anaesthetized; the blood and the kidney harvested for blood glucose analysis and routine histological procedures, respectively. Raw data obtain were expressed as mean ± standard error of mean (M ± SEM) and subjected to one way analysis of variance (ANOVA) using primer software (version 3.01) and post-hoc analysis using the Newman-Kuel test. P < 0.05 was regarded as being significant. It is observed that administration of ethanolic extract of M. oleifera seed immediately after aspartame consumption, adequately checkmated rise in blood glucose level and maintain it at the optimum level along the normal reference range. Weight gain is observed within groups and across the groups of rats, suggesting that aspartame plays no useful role in weight loss. N-hexane extract of M.oleifera seed has the capacity to curtail the destruction of tissue architecture induced by aspartame, unlike ethanolic extract of M. oleifera seed. Hence, this study provides new insight on being cautious in consuming aspartame.