International Journal of Advances in Nephrology Research http://journalijanr.com/index.php/IJANR <p style="text-align: justify;"><strong>International Journal of Advances in Nephrology Research</strong>&nbsp;aims to publish&nbsp;high-quality&nbsp;papers (<a href="/index.php/IJANR/general-guideline-for-authors">Click here for Types of paper</a>) on all aspects of&nbsp;Nephrology. This journal facilitates the research and wishes to publish papers as long as they are technically correct, scientifically motivated. The journal also encourages the submission of useful reports of negative results. This is a quality controlled,&nbsp;OPEN&nbsp;peer-reviewed, open access INTERNATIONAL journal.</p> International Journal of Advances in Nephrology Research en-US International Journal of Advances in Nephrology Research Assessment of Knowledge, Attitudes and Practices of Nurses Regard Infection Control Program in El-Hawwary Renal Dialysis Centre in Benghazi City, Libya http://journalijanr.com/index.php/IJANR/article/view/30091 <p><strong>Background:</strong> Hospital-acquired infection (HAI) is one of the common health issues and difficulties faced by hospitals in all countries over the world. Since nurses are part of the healthcare team that perform an essential role in the control of hospital infection, this study is conducted to investigate the knowledge, attitudes and practice of nurses regarding infection control measures and precautions for hospital infection.</p> <p><strong>Methods and Materials:</strong> This is descriptive cross-sectional conducted on "El-Hawary Renal Dialysis Centre" in Benghazi city, Libya in 2017. The data collection instrument is composed of a self-structure questionnaire based on precautions suggested by the World Health Organization (WHO) and the United States Centers for Disease Control and Prevention (CDC). Data were fed into the SPSS software v.22 and were analyzed using descriptive and inferential statistics.</p> <p><strong>Results:</strong> The result found that 88% of nurses reporting the higher level of exposure to the biohazards particularly, needle stick injury. In addition, most nurses do not have a good knowledge, attitudes and practices about infection control measures even though having an average &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;efficacy.</p> <p><strong>Conclusion:</strong> As the outcomes show a low level of awareness among the nurses regarding hospital acquired infection, it is proposed to offer training sessions on the prevention and control of HAI in order to upsurge the awareness of nurses in the renal dialysis centre and hold practical courses for practicing these principles in relation to the application of the standard health precautions of WHO and CDC guidelines. Further studies should be implemented.</p> Amal Ali Mukhtad Rawand Ramadan Alfahkry Wafa Owhida Mousa Amani M. Alzawi Abeer Abd El-Alali Abd El-Razik ##submission.copyrightStatement## 2019-04-24 2019-04-24 1 10 Bioassay-guided Fractionation of Carica papaya Seed Extracts against Potassium Bromate-induced Nephrotoxicity Detected Fatty Acid-rich Compounds and Prevents Oxidative Stress in Rat’s Kidney http://journalijanr.com/index.php/IJANR/article/view/30092 <p><strong>Aim:</strong> To evaluate the effect and identify the bioactive constituents of <em>Carica papaya </em>seed with potency against potassium bromate –induced nephrotoxicity and oxidative stress in renal tissue of rat.</p> <p><strong>Study Design: </strong>For each state of polarity, twenty male Wistar rats were divided into four groups, five rats per group; normal control, KBrO<sub>3</sub> control, <em>papaya</em> fraction control and KBrO<sub>3</sub> group administered with required concentration of extract of <em>C. papaya </em>seed for 48 hours.</p> <p><strong>Place and Duration of Study:</strong> Department of Biochemistry Laboratory, Faculty of Basic Medical Sciences, Bayero University Kano, Nigeria.</p> <p><strong>Methodology: </strong>&nbsp;A bioassay-guided screening of powdered <em>C. papaya </em>seed and its fractions was carried out against KBrO<sub>3 </sub>–induced nephrotoxicity and oxidative stress. The tests carried out include serum urea, creatinine, uric acid and electrolytes. Also the following markers of oxidative stress were assayed in renal homogenates; superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), reduced glutathione (GSH) and malondialdehyde (MDA). Spectroscopic analysis of the most active fraction was also carried out.</p> <p><strong>Results: </strong>Fractionation of <em>C. papaya </em>seed yielded fractions and sub-fractions that prevent KBrO<sub>3 </sub>–induced increases in serum urea, creatinine, uric acid and electrolytes as well as the level of MDA. Furthermore there were increases in activities of SOD, CAT, GPx and level of GSH. F1 was the most active fraction. Spectroscopic analysis of F1 identified six functional groups and ten compounds. Seven of the compounds have been previously reported to possess antioxidant activities:&nbsp; 9-octadecenoic acid (z)- 2- hydroxyl-1- (hydroxymethyl) ethyl ester, 17-octadecynoic acid, Hexadecanoic acid methyl ester, 1,2-benzenedicarboxylic acid butyl 2-ethylhexyl ester, 9,12-octadecadienoic acid (z,z) methyl ester, 10-octadecenoic acid methyl ester and 9,17-octadecadienal (z).</p> <p><strong>Conclusion: </strong>Fractions of <em>C. papaya </em>seed contain bioactive compounds that could prevent KBrO<sub>3</sub> –induced nephrotoxicity and oxidative stress in rats however isolation and administration of each compound was recommended for a more convincing result.</p> M. A. Kanadi A. I. Abdullahi A. Idi I. U. Muhammad A. Mohammed A. M. Wudil ##submission.copyrightStatement## 2019-07-20 2019-07-20 1 12